Diagnostic Hysteroscopy & Biopsy
Juan Diego Villegas-Escheverri MD - Under Construction
KEY POINTS
Performance of diagnostic hysteroscopy can provide information regarding the internal structure of the cervical canal and endometrial cavity, and can be used to direct the performance of an endometrial biopsy, demonstrated here. The procedure should be performed in an environment that is not resource intense - preferably in an office setting where it can be accomplished with reduced overall expense for patients and the healthcare system, and in comfort for the vast majority of people. Ideally, patients should benefit from the ”see and treat” strategy, as currently a huge number of conditions can be treated as soon as diagnosed through hysteroscopy (1,2).
INDICATIONS for DIAGNOSTIC HYSTEROSCOPY
Without any doubt, hysteroscopy is currently the gold standard for the examination of the cervical-uterine cavity in women with suspected endometrial pathologies. The main indications for hysteroscopy include examination of the uterine cavity for menstrual or fertility disorders, direct access for intra-uterine surgery, adhesions, intrauterine devices retrieval or Müllerian abnormalities, among others (1,2).
PATIENT PREPARATION
General Considerations
In order to perform hysteroscopy, the surgeon must have clear indications for the procedure. It is also especially important to ensure that the patient has as much information as possible about their condition and the anticipated risks and benefits of any procedure. A complete and focused history and physical exam should be performed, in order to have a complete picture of the patient’s condition. Potential contraindications to the hysteroscopic approach should be identified, including pregnancy or active pelvic infection. All previous imaging and lab testing need to be reviewed. After completing the evaluation the procedure can be scheduled. Office procedures can actually be performed the same day of the initial visit, but this decision depends on patient’s choice, the particular clinical features, available technology, office environment, local requirements and regulatory compliance. Although it is generally preferable to do the procedure when the endometrium is thin, a circumstance that facilitates a more accurate evaluation. Naturally, this occurs in postmenopausal women, or, for those ovulatory women in their reproductive years, early in the follicular phase of the cycle but within a few days of the end of the period. For others, a thin endometrium can be created using a spectrum of medications but most commonly progestins or combined estrogen/progestin compounds. In some instances, and particularly when evaluating for malignancy, diagnostic hysteroscopy should be performed without such suppression and in an expeditious fashion. It is especially important to assure patients have the adequate information about their condition and the procedure before performing it.
Informed Consent
As with any procedure, patients should be provided complete and adequate information in an understandable fashion based on language, culture and educational level. Included are the reasons for the hysteroscopy, alternatives to the hysteroscopic approach, and the potential adverse effects including those related to anesthesia and the procedure, such as perforation or failure to access the endometrial cavity. The clinician must ensure that the informed consent form is read completely, and they should be provided both verbally and via written materials adequate information to ensure understanding of their condition their condition and the indications for the procedure.
Preprocedure Preparation
Patient
For an office hysteroscopy, no preparation is needed unless medical suppression is required as discussed above. Presurgical AINEs, prophylactic antibiotics or cervical ripening medications are not routinely indicated but may be considered on a case by case basis. Preprocedure fasting is unnecessary if the procedure is performed using no or local anesthesia and medical leave beyond the day of the procedure is generally unnecessary. If performed under nor or local anesthesia the patient can expect go back to their regular activities immediately after the hysteroscopy. Pregnancy should be systematically excluded on the procedure day, and the clinician should take steps to be as sure as possible that there no evidence of an abdominal-pelvic infection.
Surgical Team
For the surgeon and team, it is essential that there is both adequate training and surgical expertise, including complete knowledge of surgical principles and equipment. The design and elements of the procedure room have been described elsewhere, and should be be ready, not only for the procedure, but for the possibility of adverse events. There should be consideration for the provision of adequate analgesia/anesthesia if needed. Appropriate hysteroscopic and ancillary instruments and supplies must be available. The room environment should foster a sense of comfort including the room temperature, appropriate music and décor.
PROCEDURE STEPS
- The patient is placed in the modified lithotomy position with the buttocks at the very edge of the operating or procedure table to allow unimpeded movement of the hysteroscope during the procedure.
- Vaginoscopic Technique. Carefully insert the hysteroscope into the vagina. If necessary, the vagina can be sealed by carefully compressing the labia major um with the thumb of the free hand, providing lateral support over the entire genital area.
- The liquid distention media is turned on to convert the vagina from a virtual to a real cavity. For most diagnostic hysteroscopic procedures, isotonic solution is preferred as distention media.
- The first step in the vaginoscopic technique is to evaluate the vagina for pathology and to identify the exocervix and the cervical canal. This is accomplished by advancing the hysteroscope cephalically and posteriorly and, if a foreoblique lens is used, with it angled up, toward the ceiling.
- When the external cervical os is located under direct vision, the long axis of the hysteroscope is aligned with that of the cervical canal and then advanced, rotating the sheath as necessary for optimal visualization, and minimizing contact with the cervical walls as much as possible. Pathology located in the cervical canal should be noted.
- This process is continued until the internal cervical os is identified and the endometrial cavity entered.
- The endometrial cavity is completely evaluated in a systematic manner that could be in this order: Anterior wall, Uterine fundus, Both ostium and Posterior wall). With 0ᴼ hysteroscopes this involves evaluation from the level of the internal os, and movement horizontally and vertically adequate to provide the most complete view possible. For foreoblique scopes (12ᴼ-30ᴼ) the same movements are performed, but extent of the horizontal and vertical movements are reduced substantially but replaced by the need to rotate the hysteroscope in a way that exposes all of the surfaces. This is especially true in the cornual areas, that may not be visible with 0ᴼ instruments.
- If a targeted lesion such as a polyp is seen, it should be removed if such removal is feasible based on size, patient comfort, and available equipment (See Section on Polypectomy – link)
- If a targeted endometrial biopsy is indicated, it is performed at this time.
- The valve on the operating channel of the hysteroscopic assembly is opened.
- The biopsy forceps are passed into the channel - be careful that they are the correct diameter to match the diameter of the channel - carefully until it is seen on the screen.
- The hand operated system is used to open the forceps jaws the device carefully advanced under hysteroscopic vision until the target is reached.
- The opened forceps are gently pushed against the target area and then the jaws are compressed to secure the specimen.
- At this point one of two approaches can be used. The first is to leave the sheath in place while withdrawing the forceps through the operating channel. The specimen can then be lifted out of the jaw with a tissue forceps or a needle and placed in appropriate formalin solution. For larger specimens that are of greater diameter than the channel, the specimen will be lost unless the entire hysteroscopic system is removed after drawing the forceps close to the location of the lens.
- Repeat biopsies are performed until the surgeon is satisfied that adequate tissue from all of the targeted areas has been obtained.
- The hysteroscopic assembly is removed from the uterus
POST-PROCEDURE CONSIDERATIONS
After the procedure, patients can be sent home with general instructions, modified, as appropriate to their clinical situation. Patients may have lower abdominal pain for 45 to 60 minutes after the procedure. If the discomfort is intense, common pain relievers can be indicated, including paracetamol or NSAIDs. Fluid (water or water-blood) will leak through the vagina during the day after procedure. Patients should be reassured that this is completely normal. Depending on the complexity of the procedure and the patient’s response, activities of daily living can generally be resumed without restriction. Arrangements should be made for conveying the results of the biopsy, if taken.
REFERENCES
1. Vitale SG, Haimovich S, Riemma G, Ludwin A, Zizolfi B, De Angelis MC, Carugno J. Innovations in hysteroscopic surgery: expanding the meaning of "in-office". Minim Invasive Ther Allied Technol. 2020 Jan 23:1-8.
2. Vilos GA, Abu-Rafea B. New developments in ambulatory hysteroscopic surgery. Best Pract Res Clin Obstet Gynaecol. 2005 Aug;19(5):727-42
3. Angioli R, De Cicco Nardone C, Plotti F, Cafà EV, Dugo N, Damiani P, Ricciardi R, Linciano F, Terranova C. Use of music to reduce anxiety during office hysteroscopy: prospective randomized trial.J Minim Invasive Gynecol. 2014;21(3):454 Paragraph
4. Cholkeri-Singh A, Sasaki KJ. Hysteroscopy safety. Curr Opin Obstet Gynecol. 2016 Aug;28(4):250
5. Salazar CA, Isaacson KB. Office Operative Hysteroscopy: An Update. J Minim Invasive Gynecol. 2018 Feb;25(2):199
6. https://elearning.rcog.org.uk//uterine-cavity-surgery/diagnostic-hysteroscopy/preparation-hysteroscopy
7. Keyhan S, Munro MG. Office diagnostic and operative hysteroscopy using local anesthesia only: an analysis of patient reported pain and other procedural outcomes. JMinimInvasive Gynecol. 2014 Sep-Oct;21(5):791-8.
DIAGNOSTIC IMAGES