Electrosurgery in the Uterus
KEY POINTS
- Electrosurgery can be defined as the application of RF alternating current to tissue resulting in elevation of intracellular temperature that is adequate to result in tissue vaporization or coagulation
- Radiofrequency electricity is based upon alternating current (AC) where the polarity of the two electrical poles in the circuit changes with each half cycle
- The frequency of alternating the polarity of the two electrodes occurs about 400,000 to 500,000 times per second, or 400 to 500 kiloHertz, a similar frequency to AM radio from which the term "radiofrequency" gets its name.
- The rapid switching of polarity means that there is no flow of electrons around a circuit - instead the electrons oscillate at this rapid rate, an example of the conversion of electromagnetic energy to kinetic energy
- This rapid oscillation of ions within the cell results in the conversion of kinetic energy to thermal energy, which is responsible for the increase in intracellular temperature
- Rapid focused elevation of temperature results in cellular vaporization, which can be extended in a linear fashion to cut tissue.
- Less rapid, less focused elevation of intracellular temperature results in both cellular desiccation and protein coagulation - the basis behind the "sealing" effect of RF electrosurgery.
- Learning to control these two effects effectively and safely is the responsibility of the hysteroscopic surgeon.
INTRODUCTION
Although laser energy sources have been described for operative hysteroscopy, it has long been evident that radiofrequency (RF) electrical energy offers the optimal combination of effectiveness, efficiency, safety and acceptable cost. The use of RF electrical energy at surgery is often called “electrosurgery”, a process that can be defined as the application of RF alternating current tissue resulting in elevation of intracellular adequate to result in tissue vaporization or coagulation. The intrauterine environment, together with the need operate in fluid media, present challenges both to hysteroscopic surgeons and to the designers and manufacturers of of hysteroscopic surgical equipment. Indeed, most of these challenges have been shared by surgeons operating in the urinary bladder as described in the section on “History of Hysteroscopy”. Fortunately, more than 140 years of development has allowed RF electrosurgery to be conducted within the uterus in a safe and effective fashion. However, part of the safety paradigm is the need for the surgeon to be familiar with electrical principles and their safe application during hysteroscopic surgery.
FUNDAMENTALS OF ELECTROSURGERY
During RF electrosurgery, high frequency electromagnetic energy is converted in the cell first to kinetic energy, then to thermal energy. Rapid intracellular heating to 100ᴼ C results in boiling of the intracellular water, that comprises a liquid to gas conversion that results in rapid volumetric expansion and cellular rupture – a process called “vaporization”. If the elevation in intracellular temperature remains below100ᴼ C but above 60ᴼ C, two processes occur; one is the loss intracellular water is by dehydration (desiccation); and the other a breakdown in the protein molecular bonds, which when they reform create a homogenous coagulum that is collectively a process called coagulation. The type of tissue effect achieved is determined by variety of factors that include those that relate to RF electrical properties as well those related to the interface between the electrode and tissue, including the tissue exposure time, the size and shape of the electrode, and the relationship of the electrode to the target tissue.
Electrosurgical Circuits
RF electrosurgery requires the creation of a contiguous circuit allowing the passage of electrons. The elements of a circuit that include the two electrodes, the electrosurgical generator or unit (ESU) the wires that connect them, and, of course some part of the patient. All RF electrosurgery requires two electrodes, at least one of them designed to create a tissue effect, a circumstance that makes all RF electrosurgery “bipolar”. The difference between bipolar and monopolar instruments is the location and purpose of the second electrode.
Monopolar instruments are designed such that one electrode is used for concentrating the current and generating the tissue effect, while the other electrode, the dispersive electrode, is placed remotely on the patient and is designed not to result in increased tissue temperature. On the other hand, bipolar instruments contain both electrodes – in some instances both create a tissue effect (such as bipolar laparoscopic coagulation devices), while in others the second electrode functions as dispersive electrode designed not to create a tissue effect. While the entire patient should be considered part of the circuit with monopolar instruments, for bipolar devices the only aspect of the patient involved in the circuit is that grasped by, or adjacent to, the two electrodes. Dispersive electrodes simply “defocus” the energy in a way that limits or eliminates the ability to elevate tissue temperature to the level of a tissue effect. The terms “Neutral Electrode”, “Grounding Pad” and “Return Electrode” are all incorrect as there is RF energy, there is no “grounding” of contemporary systems and in an alternating current electrons undergo bidirectional oscillation, not unidirectional flow.
Fundamentals of Electricity
There are three fundamental and interacting properties of electricity that necessary to understanding RF electrosurgery. These include current (I), voltage (V) and impedance or resistance (R). Current is the measure of the movement of electrons past a given point in the circuit in a defined period of time and is measured in amperes. The concept of voltage is one of pressure, in this instance the difference in electromotive pressure between the two electrodes, and which reflects the pressure with which the electrons are pushed through the circuit. It is measured in volts. Resistance, measured in ohms, reflects the difficulty that the circuit, or a part of the circuit presents to the passage of electrons. Technically, the term resistance is reserved for constant polarity circuits (also called direct current circuits, or DC) while for alternating polarity circuits the term impedance is the appropriate term. In any electrical circuit these electrical properties are related by Ohm's Law: I = V/R. Power reflects work per unit time, is calculated as the product of current and voltage and is measured in watts (W = V x I). If Ohm's Law is used to create a substitution for current [W = V x (V/R)], then wattage can be expressed in another way (W = V2/R).
Understanding the relationships between V, I and R can be helpful when explaining the phenomenon of electrosurgery. For example, the "pressure" created by increasing voltage pushes facilitates arcing between the electrode and tissue across a gap filled by a highly impedant gas (air). Similarly, when in contact with tissue, this voltage induced electrical “pressure” forces more energy into the tissue, a circumstance that results in a greater degree of thermal injury. The power equation (W = V2/R) shows how a simply designed ESUs will diminish their output voltage as tissue impedance increases a circumstance that more sophisticated systems overcome by adjusting voltage to a degree what Wattage stays constant.
RF Electrosurgical Generators and Waveforms
The ESU converts the 60 cycle per second (60 Hertz or Hz) waveform from a standard AC output, into a radiofrequency current that typically ranges from 300 to 500 Kilohertz (KHz). If such a RF output is viewed on the screen of an oscilloscope, it is displayed as a waveform that is usually symmetrical above and below "0" volts, a circumstance that reflects the alternating polarity of the circuit. The peak voltage of the generated waveform is depicted by the distance from the baseline to the apex of the wave.
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In many ESUs manufactured for the North American market, the lowest voltage output is labelled 'cut', a continuous waveform, typically depicted on an oscilloscope in the form of a sine wave. The modulated (interrupted), high voltage waveform, in North America called 'coagulation', is largely designed for the process of fulguration, explained below but a comprising process of superficial coagulation, desiccation and carbonization of tissue. Blended currents are not a combination of these two, as the name would suggest. Instead, these waveforms are modulated (interrupted) versions of the low voltage output, the interruption serving to allow for a modest increase in voltage with the same watt setting (W= I X V). Typically the “blended” output has a “duty cycle” of 50 to 80%, meaning that the waveform is interrupted for about 20 to 50% of the cycles. For the “coagulation” mode, the duty cycle is typically about six per cent, a proportion that allows the voltage to rise substantially for a given Wattage output.
ESUs vary substantially with respect to frequency, peak voltages at given settings and the duty cycles of the various "blend" modes, to name only a few. Most ESUs designed for operating room use have the capability of supporting generic bipolar systems, but most bipolar systems in use require a proprietary generator. Regardless, only low voltage continuous outputs are used for bipolar systems. Consequently, the surgeon should make herself or himself intimately familiar with the function, features and controls of the ESU used for hysteroscopic surgery.
Cellular and Tissue Effects of Electrosurgery
Electrosurgical tissue effects depend upon a number of factors including the ESU power setting and waveform, target tissue impedance, the type of distending media and the shape and size of the electrode and its proximity to tissue. A concept that is critical to the understanding of electrosurgical tissue effects is current or power density, the total wattage striking the tissue per unit area. When the ESU output is held constant, power density is determined by the shape and size of the electrode and by its relationship to the tissue - contact vs. non-contact. An electrode with a small surface area such as a needle or a wire loop, when held in proximity to tissue, will concentrate currant so the energy is focused on a small area that facilitates rapid elevation of cellular temperature and the creation of a narrow zone of vaporization. If the electrode is changed to a wider, larger design such as a ball or barrel the power density is diluted somewhat to that the temperature is enough only to dehydrate and coagulate the tissue. The opposite power density extreme the dispersive electrode, with a surface area so large that it dissipates the current thereby preventing significant elevation in tissue temperature.
Cutting
During hysteroscopic surgery, tissue cutting is best achieved with a continuous or near continuous low voltage output, using a pointed or or loop shaped electrode held adjacent to tissue. Provided the voltage is adequate, and the electrode is near to the tissue, vaporization occurs, which, in fluid media manifests with simultaneous transaction and the formation of gas bubbles from the intracellular liquid gas conversion, that become free in the media. The depth of thermal injury in the remaining tissue depends on a number of factors including the ESU power output and waveform, the electrode size and shape and the speed and skill of the surgeon. While the minimum depth of thermal injury has been described as low as a few microns, more typical reported endomyometrial injury studies suggest about 0.2 to 1.0 mm.
Bulk Vaporization
Bulk vaporization describes the use rather large surface area to remove large tissue masses with electrosurgical vaporization. The technique requires a high-power output and its function can be facilitated by a design that includes grooves or spikes that can concentrate current. To achieve the required power in monopolar systems, the ESU is typically set at three to four times the power required for loop or needle electrodes. When using this technique, surgeons should be reminded to safe a tissue specimen for histopathological examination.
Desiccation/Coagulation
As previously discussed, tissue coagulation comprises the combination of cellular and tissue dehydration and coagulation, the latter a process whereby tissue proteins are denatured and reconstituted into a homogenous coagulum. Coagulation is achieved by placing an electrode with a relatively large surface area on the target tissue, followed by activation of the ESU. Preferably, low voltage outputs are preferred as the modulated, high voltage outputs called “coagulation” in North America tend to cause only a superficial effect. As previously stated, all bipolar systems are designed to be used with low voltage waveforms. Provided the selection of an appropriate electrode, any waveform may be used to create tissue coagulation. However, the cutting and blended outputs for monopolar instruments are preferred to those labeled "coagulation" because they are at least equally efficacious and they are not associated with the risks of current diversion. High voltage outputs damage electrodes more quickly and are associated with an increased risk for capacitative coupling, to be discussed later.
Fulguration
The process of fulguration generally applies to electrosurgery in gaseous media. The dynamics are vastly different in fluid media. Fulguration is is also known as spray coagulation or black coagulation, being a technique that superficially coagulates and carbonizes tissue using the repeated high voltage electrosurgical arcs, that, when applied to desiccated tissue, induce the process of resistive heating that can quickly elevate the temperature to 200C or more resulting in organic breakdown and release of the carbon atoms that provide the black appearance.
COMPLICATIONS
The major complications of intrauterine RF electrosurgery are uterine perforation and current diversion, the latter related only to monopolar instrumentation.
Uterine Perforation
If the uterus is perforated with an activated electrode there is a high risk of trauma to surrounding structures, most likely bowel, but also blood vessels and the lower urinary tract including bladder and ureter. Fortunately, such a complication cannot occur unless the surgeon moves the activated electrode away from the hysteroscope or resectoscope. Avoidance of this activity doesn’t prevent perforation per se, but it will likely largely if not totally eliminate the risk of trauma to surrounding structures. If, for some reason, perforation occurs and the electrode's activation status is unknown, abdominal exploration should be the rule, just as it is if it is known that an activated electrode has perforated the uterus.
Current Diversion and Vulvovaginal Thermal Trauma
Current diversion with resulting thermal trauma to the cervix, vagina and/or vulva is a possible complication of RF electrosurgery with monopolar systems. The key to avoiding these adverse events is an understanding of the mechanisms involved. Indeed, if bipolar systems are used, such events cannot occur.Radiofrequency electrical energy can be transferred between two adjacent but unconnected circuits by capacitative coupling, a phenomenon that is actually part of the function of an intact monopolar RF resectoscope. Capacitative coupling normally occurs between the long shaft of the activated electrode and both the internal sheath and telescope. Then, there is subsequent capacitative coupling between the internal sheath and the external sheath of the resectoscope in all instances of electrode activation. The external sheath should be in intimate contact with the cervix, a circumstance that, because of the large surface area prevents focusing of the energy so that the interface actually facilitates completion of the patient portion of the circuit between active and dispersive electrodes. However, if the intimate relationship of the external sheath and the cervix is lost, and replaced by a zone of contact with the vagina or vulva that has a small surface area, the scenario for a high power (current) density zone and resultant burn can be created.
There exist a number of operating principles that should serve to reduce the risk of such injuries, understanding that the use of bipolar systems is likely the best option. First and foremost, electrodes with damaged insulation should be destroyed – it would be best if a new electrode is used for each case. High voltage (“coagulation”) outputs should be avoided since such waveforms probably facilitate these complications either by electrode insulation damage or by a voltage induced increased the risk of capacitative coupling. Perhaps most importantly is the need to maintain intimate contact between the external sheath and the cervix. This is accomplished by avoiding overdilation of the cervical canal and by keeping the external sheath in contact with entire cervical canal during electrode activation. Finally, the electrode should be activated only when near or in contact with the target tissue, a circumstance that minimizes the “open circuit” needed for capacitative coupling.
Other Electrosurgical Complications
Direct coupling can be associated with monopolar hysteroscopic instruments. Any metallic object including speculae and cervical tenaculi also can, following contact with the external sheath, serve to conduct current to locations in the vagina and vulva. Care should be taken to avoid contact of these instruments with the resectoscope.
Another circumstance is accidental activation. For example, if the resectoscope is left on the patient’s abdomen, and connected to the generator, there is a risk for the patient. A staff member, medical student, or the surgeon her or himself may inadvertently depress the footpedal. In such instances either the active electrode or the sheath, by way of capacitative coupling can cause burns to the patient directly, or via the instigation of a fire by igniting the drapes.
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